Pregnancy After Breast Cancer in Young BRCA Carriers

Matteo Lambertini; Eva Blondeaux; Elisa Agostinetto; Anne-Sophie Hamy; Hee Jeong Kim; Antonio Di Meglio; Rinat Bernstein Molho; Florentine Hilbers; Katarzyna Pogoda; Estela Carrasco; Kevin Punie; Jyoti Bajpai; Michail Ignatiadis; Halle CF Moore; Kelly-Anne Phillips; Angela Toss; Christine Rousset-Jablonski; Fedro A Peccatori; Tiphaine Renaud; Alberta Ferrari; Shani Paluch-Shimon; Robert Fruscio; Wanda Cui; Stephanie M Wong; Claudio Vernieri; Kathryn J Ruddy; Maria Vittoria Dieci; Alexios Matikas; Mariya Rozenblit; Cynthia Villarreal-Garza; Laura De Marchis; Lucia Del Mastro; Fabio Puglisi; Maria Del Pilar Estevez-Diz; Kenny A Rodriguez-Wallberg; Bela Mrinakova; Sarah Meister; Luca Livraghi; Florian Clatot; Rinat Yerushalmi; Carmine De Angelis; Rodrigo Sanchez-Bayona; Icro Meattini; Natalia Cichowska-Cwalinska; Martine Berliere; Mahmoud Salama; Ugo De Giorgi; Amir Sonnenblick; Camila Chiodi; Young-Jin Lee; Camille Maria; Hatem A Azim; Luca Boni; Ann H Partridge

Journal article

Pregnancy After Breast Cancer in Young BRCA Carriers

Matteo Lambertini, Eva Blondeaux, Elisa Agostinetto, Anne-Sophie Hamy, Hee Jeong Kim, Antonio Di Meglio, Rinat Bernstein Molho, Florentine Hilbers, Katarzyna Pogoda, Estela Carrasco, Kevin Punie, Jyoti Bajpai, Michail Ignatiadis, Halle CF Moore, Kelly-Anne Phillips, Angela Toss, Christine Rousset-Jablonski, Fedro A Peccatori, Tiphaine Renaud, Alberta Ferrari Show all

JAMA: Journal of the American Medical Association | American Medical Association | Published : 2024

DOI: 10.1001/jama.2023.25463

Abstract

Importance: Young women with breast cancer who have germline pathogenic variants in BRCA1 or BRCA2 face unique challenges regarding fertility. Previous studies demonstrating the feasibility and safety of pregnancy in breast cancer survivors included limited data regarding BRCA carriers. Objective: To investigate cumulative incidence of pregnancy and disease-free survival in young women who are BRCA carriers. Design, Setting, and Participants: International, multicenter, hospital-based, retrospective cohort study conducted at 78 participating centers worldwide. The study included female participants diagnosed with invasive breast cancer at age 40 years or younger between January 2000 and Dece..

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University of Melbourne Researchers

Kelly Phillips Author

Wanyuan Cui Author

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Grants

Awarded by Italian Association for Cancer Research (AIRC)

Awarded by Korea Health Technology RAMP;D Project through the Korea Health Industry Development Institute(KHIDI) - Ministry of Health and Welfare, Republic of Korea

Awarded by Cancer Australia

Awarded by National Breast Cancer Foundation

Awarded by Australian National Breast Cancer Foundation

Awarded by Australian National Health and Medical Research Council

Awarded by US National Institutes of Health

Funding Acknowledgements

The study was partly supported by the Italian Association for Cancer Research (AIRC grant MFAG 2020 ID 24698), and the 2022 Gilead Research Scholars Program in Solid Tumors. Dr Lambertini received support from the European Society for Medical Oncology (ESMO) for a translational research fellowship at the Institut Jules Bordet in Brussels, Belgium, at the time this study was initiated. Dr Kim receives support from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant HC20C0135). Dr Phillips is a Australian National Health and Medical Research Council leadership fellow. Data collection for most Australian participants was through the kConFab Follow-Up Study with support from Cancer Australia and the National Breast Cancer Foundation (PdCCRS 1100868), Cancer Australia (809195), the Australian National Breast Cancer Foundation (IF 17), the Australian National Health and Medical Research Council (454508, 288704, and 145684), the US National Institutes of Health (1RO1CA159868), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania, and South Australia, and the Cancer Foundation of Western Australia. Dr Partridge receives support from the Breast Cancer Research Foundation and Susan G. Komen.